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J R Wheaton Selected Research

IMP Dehydrogenase

7/2001Targeting of human Tmolt4 leukemic type II IMP dehydrogenase by cyclic imide related derivatives.
4/2001Tmolt4 leukemic type II isoform of IMP dehydrogenase as a target for 1,2,4-triazolidine-3,5-diones, 1-(1-(3-methylphenyl)ethylidineamino)-4,4-diethyl-3,5-azetidinediones, 3,5-isoxazolidinediones, and 4,4-disubstituted-3,5-pyrazolidinediones.
1/2001The cytotoxicity of 1-(1-phenylalkylideneamino)-2,4-azetidinediones and their mode of action in human and murine tumor cells.

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J R Wheaton Research Topics

Disease

3Leukemia
04/2001 - 01/2001
2Lymphoid Leukemia
02/2001 - 01/2001
2Lymphoma (Lymphomas)
02/2001 - 01/2001
1T-Cell Leukemia (Leukemia, T Cell)
07/2001
1Neoplasms (Cancer)
01/2001
1Adenocarcinoma
01/2001
1Carcinoma (Carcinomatosis)
01/2001
1Osteosarcoma (Osteogenic Sarcoma)
01/2001

Drug/Important Bio-Agent (IBA)

3IMP DehydrogenaseIBA
07/2001 - 01/2001
3DNA (Deoxyribonucleic Acid)IBA
04/2001 - 01/2001
2purineIBA
04/2001 - 01/2001
2EnzymesIBA
04/2001 - 01/2001
2Cytotoxins (Cytolysins)IBA
02/2001 - 01/2001
1AzepinesIBA
07/2001
1Protein Isoforms (Isoforms)IBA
04/2001
1RNA (Ribonucleic Acid)IBA
01/2001
1TransferasesIBA
01/2001